Pet Supplement Ingredients Backed
by Science

Bilear™ brand Artichoke Leaf Extract to help normalize liver metabolism and promote bile flow.

Bilear™ is a standardized dry extract from the leaves of Cynara cardunculus L. commonly referred to as artichoke. Artichoke flower buds have long been used to stimulate the production and flow of bile from the liver to the intestine. This effect is achieved through stimulation of the enzymatic, functional and antitoxic activities of the liver.

The C3™ (Colostrum Calming Complex) is a mixture of bioactive proteins produced from a special microfiltration process of certified bovine colostrum. This specific fraction of the colostrum possesses proven calming or anxiolytic properties. The carefully monitored process assures the bioactive components are separated and isolated without the application of denaturing heat or physical stressor. The C3™ Complex contains bioactive, proline-rich proteins, special monosaccharides and specific fatty acids that work together to enhance the calming activity of the colostrum fraction.

The Colostrum Calming Complex supports brain activity, relaxation and cognitive function. Its effectiveness in dogs and cats may be due in part to its ability to enhance the effect of Gamma-Amino Butyric Acid (GABA), a neurotransmitter that inhibits brain activity. It is thought that the C3™ Complex provides molecular precursors that support the calming response by normalizing cognitive and brain functions associated with excessive brain activity.

Casperome® is a highly standardized and purified mixture of the tripenoid acids found in the gum resin of Boswellia serrata. Due to the digestive tract's poor absorption of these compounds, Casperome® has been formulated using the advanced Phytosome® technology to optimize bioavailability of active components. When complexed with selective phospholipids, the formulation offers a significant increase in both plasma and tissue concentrations (such as those found in the eye and brain) of the key components in Boswellia.

The key mode of activity for Casperome® lies in its proven ability to support a healthy inflammatory response in both in vitro and animal studies. Boswellic acids, such as 11-keto-beta Boswellia (KBA) and its acetylated counterpart (AKBA), act as selective 5-lipoxygenase inhibitors, resulting in Boswellia?s ability to manage the inflammatory response. Recent findings suggest its capability to modulate both the inflammatory response of the proinflammatory cathepsin enzymes and the microsomal prostaglandin E-synthase. Boswellia extracts have shown their effectiveness in management of inflammatory responses in the joints, bowels, bones, respiratory system, skin and brain.

Curcumin is the principle curcuminoid orange pigment found in Tumeric, which offers potent antioxidant properties and promotes a healthy inflammatory response in dogs and cats. CurcuVET® is the branded curcumin product from Indena which offers improved oral absorption by incorporating Phytosome® technology. This process complexes curcumin with phoshatidylcholine, which provides hydrolytical stability, as well as increases absorption and bioavailability of curcumin to the body. Pharmacokinetic studies demonstrate a nearly 30-fold increase in bioavailability as compared to standard curcumin extracts.

CurcuVET®'s mode of activity focuses on its ability to both maintain a healthy inflammatory response and provide antioxidant and hepatoprotective activity. As an antioxidant, curcumin has been shown to be an effective scavenger of both ROS and reactive nitrogen species in vitro. It can also inhibit the activity of inflammatory enzymes, such as MMP-9, and promote the synthesis of Glutathione. Extensive studies have proven curcumin to be a potent COX-2 and 5-LOX inhibitor and consequently an important supplement to support joint health.

CurcuVET® is becoming the supplement of choice to normalize the inflammatory response and provide greater comfort when dealing with conditions of the joint, liver, gastrointestinal tract, and cardiovascular system.

N,N-Dimethyglycine is an important amino acid that can demonstrate a wide variety of health-building effects in companion animals. VetriScience® research has shown that this versatile ingredient can improve physical and mental performance, reduce the stress response, and improve cellular pathways by providing key building blocks, such as methyl groups and other metabolic intermediates found in the methylation cycle. DMG can support cardiovascular health, liver function, detoxification, neurological health and brain activity. DMG can enhance both the humoral and cellular immune response.

A number of patents have been issued to FoodScience® Corporation, the parent company of VetriScience® Laboratories, for the use of DMG, including US Patent #7,229646B2.

The combination was effective in reducing specific markers for the condition including anti-nuclear antibodies and inflammatory cytokines.

N,N-Dimethylglycine can demonstrate antioxidant and immune system effects, may help reduce lactic acid buildup, support oxygenation of tissues, and provide methylation for the synthesis for many important molecules in the body including SAMe, glutathione, nucleic acids, hormones, antibodies, and neurotransmitters. Because of its wide benefits to support health and well being, DMG has been called a metabolic enhancer.

Entero-Chronic® Blend is a clinically researched blend of four ingredients.

• α-glucans - A fermentable polysaccharide resistant to digestion that produces Butyrate when fermented by bowel bacteria. Butyrate is the main energetic source of colonocytes ? the epithelial cells of the colon.
• β-glucans - Non-digestive polysaccharide that is the specific substrate of beneficial bacteria. Various studies suggest that beta glucans may stimulate immune function by increasing the number of T-helper cells, the activity of natural killer cells, and the levels of interferon gamma and tumor necrosis factor alpha.
• MPS Protect - A mucopolysaccharide that reinforces the intestinal mucin. Mucin is the main component of gastrointestinal mucus (formed by combining water and mucin). The function of mucus in the intestine is to lubricate the lining of the GI tract and protect from mechanical damage. Intestinal mucus reduces the ability of pathogens to attach to the intestine.
• MOS - Mannan oligosaccharides. Harmful bacteria contain specific mannose fimbriae used for attaching to the epithelium. MOS attaches to these fimbriae which prevents bacteria from attaching to the walls of the intestines. The MOS and its passenger are then voided.

GanedenBC30® is a patented lactic acid bacterial strain called Bacillus coagulans. Unlike most other probiotic strains, GanedenBC30® is a spore-forming organism which makes it highly stable and allows it to remain viable through manufacturing processes, transportation, shelf-life and consumption. It has been extensively researched in over 20 published studies for its safety, shelf stability, and survivability in stomach acid. GanedenBC30® is the only Bacillus that has obtained Generally Recognized As Safe (GRAS) status from the FDA. Specifically, it has been recognized as safe for veterinary use by the FDA Center for Veterinary Medicine after many studies to assess toxicity. ¹

1Safety assessment of a proprietary preparation of a novel Probiotic, Bacillus coagulans, as a food ingredient. (n.d.). Retrieved from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726964/.

Beta glucans are found broadly in nature and are primarily derived from yeast cell walls and medicinal mushrooms. Beta glucans are highly branched polysaccharides with antioxidant and immune enhancing properties. Glucans MY™ is a special blend of beta glucans derived from several sources that have beneficial effects on the immune, endocrine, cardiovascular, respiratory, renal and liver systems. Beta glucans are known to help maintain proper levels of bacteria within the body.

Studies suggest that beta glucans might stimulate immune function by increasing the number of T-helper cells, by increasing the activity of natural killer cells, or by increasing the levels of interferon gamma and tumor necrosis factor alpha. Beta glucans can also increase macrophage activity and support the body's normal recovery process. Because of their broad immune-enhancing properties, beta glucans have multiple applications in animal health programs.

Natural components of the Perna canaliculus mussel work together to support joint health in a number of key areas. These include supporting the joint chondrocytes? ability to biosynthesize cartilage through the ingredient?s provision of necessary building blocks, and through reduction of cartilage destroying pathways.

Research over the past 30 years has revealed that Perna contains a number of potentially active compounds that may help with joint discomfort and stiffness associated with aging. The mussel?s specialized combination (biologically active glycoproteins, chelated minerals, fatty acids, and glycosaminoglycans (GAGs)) supports the construction and repair of articular cartilage and may help reduce further deterioration of the joint.

Research has demonstrated that Perna modulates the levels of pro-inflammatory cytokines, such as TNF-alpha, IL-1-,IL-2 and IL-6, cyclooxygenase enzymes, and Immunoglobulin. The presence of chondroitin sulfates 4 and 6, hyaluronic acid, dermatan sulfate, and other key GAGs in Perna provide improved viscosity, flexibility, and tensile strength of the articular cartilage.

The principle mechanisms of action of Perna include reducing degradation of catabolic enzymes (which breakdown cartilage) and free radicals, and modulating the immune response to down regulate pro-inflammatory cytokines. Extensive clinical use in dogs, cats and horses has led to improved mobility, range of motion, and animal comfort.

HyaMax® is the standardized natural sodium salt of Hyaluronic Acid (HA) from Fenchem.

HA is a polysaccharide with a large molecular weight composed of repeating disaccharide units of Glucuronic Acid and N-acetyl glucosamine. It is a non-sulfated glycosaminoglycan (GAG) found in cartilage and joint synovial fluid, as well as in other connective tissue, skin and eyes. HA is the key component of joint tissue where it serves as the backbone of the very large proteoglycan aggregates, which, when combined with collagen, give cartilage its structure.

Its key function is to bind with large amounts of water (1000 times its own weight) for lubricating the movable parts of the joint, providing shock absorber activity. In the synovial fluid, HA acts as a lubricant to reduce wear and tear on the joints.

HyaMax® HA is a low molecular weight material (1.0 to 1.5 million Daltons). As an oral supplement, HA is primarily used to support joint and skin health.

The mechanism of action of oral intake of Hyaluronic Acid is not directly linked to providing building blocks for synthesis in the joints. Instead, once the low molecular HA is absorbed into the bloodstream, it communicates with the immune system to stimulate the production of new HA in the joint. This response improves joint lubrication, shock absorption and comfort level.

The GI tract absorbs only 5-10 percent of the HA. Because the recommended amount of HA is 0.1 mg per pound of body weight, only a relatively small amount is absorbed. Still, that small amount is adequate to stimulate the desired response. Research supports the use of HA supplements for joint health in both dogs and horses.

Theanine is the major amino acid found in green tea responsible for its relaxation property. Suntheanine® is the patented dietary supplement for stress reduction, relaxation and better sleep efficiency. This anti-stress ingredient is thought to produce its calming effect by increasing levels of GABA and serotonin in the brain, and by blocking the binding of glutamic acid to cell receptor site.

Clinical trials have shown that Suntheanine® promotes an alert state of relaxation without causing drowsiness, as indicated by an increase in Alpha brain waves and a decrease in Beta brain wave activity. Studies have demonstrated that Suntheanine® is effective in helping dogs and cats deal with separation anxiety, fear behavior and environmental stressors.

LeucoSelect® is the branded, standardized grape seed extract from Indena, which employs their Phytosome® technology for enhanced bioavailability. Grape seed extracts contain polyphenolic compounds known as oligomeric procyanidins (OPCs), which have been found to have pronounced antioxidant activity in the body. Procyanidins are derivatives of the flavin-3-ol class of flavonoids, including catechins and epicatechins. The OPCs in grape seed extracts consist of dimers, trimmers, and tetrameters, as well as higher molecular weight species, which generally have poor bioavailability. LeucoSelect® grape seed extract has a well-defined chemical composition critical to its antioxidant activity. To improve the biological activity and bioavailability, Indena has removed the higher molecular weight OPCs and concentrated the more active, smaller sized oligomers, formulating them with their patented Phytosome® technology (complexed with phosphatidylcholine).

Several clinical studies have demonstrated LeucoSelect® Phytosome®'s support for cardiovascular health. The OPCs are especially known for their capillary protective effect and for the ability to reduce oxidative stress. Their antioxidant activity and free radical scavenging is especially effective against hydroxyl and peroxyl radicals, which oxidize low-density lipoproteins. They have also been known to stimulate a healthy immune response.

Research has demonstrated LeucoSelect®'s ability to reduce oxidative stress and to support plasma antioxidant defenses, both in physiological and clinical conditions. The product represents an effective and safe way to support cardiovascular health and protect the body from free radical damage.

Magtein® (Magnesium L-Threonate): Magnesium is an essential cofactor for more than 300 enzymes involved in biosynthesis processes and energy metabolism. It plays an essential role in many of the brain?s functions. Magtein® is Magnesium I-threonate, an innovative form of magnesium shown to effectively raise the brain?s magnesium levels, which leads to enhanced learning abilities, improved working memory, and better short-and long-term memory in animals. Magtein® was discovered by a group of scientists from MIT, including a Nobel Prize laureate.

Maitake mushrooms are rich in beta glucans, and extracts of Maitake PD-Fraction® are trademarked, highly purified, and standardized to contain 30% pure D-Fraction® of the Maitake mushroom. The D-Fraction® of beta glucan is the most active and potent form. Maitake extracts support immune health by stimulating macrophage activity and activating toxic T cells and cytokines of the immune system.
The extract is considered to be one of the strongest immune builders in the arsenal of health supplements. PD-Fraction® is also valuable in supporting cardiovascular health and healthy blood sugar levels.

MicroActive® Resveratrol is a proprietary ingredient that has been micronized and encapsulated to maximize bioavailability and extend residence time of the compound. Improved absorption and extended time release allows for more of the molecule to enter the bloodstream and achieve the desired effect. MicroActive® ingredients are extensively researched and supported by more than 10 clinical studies. Resveratrol supports healthy aging through its healthy inflammatory, antioxidant, and metabolic effects.

Oligonol® is a patented, low-molecular weight polyphenolic extract derived from lychee fruit and green tea. This low weight allows for better bioavailability than conventional long-chain polyphenols. Human clinical trials show a threefold increase in blood concentration of Oligonol® versus standard lychee extract. Oligonol® has been clinically shown to increase production of nitric oxide (for improved circulation), neutralize free radicals, support healthy levels of inflammatory cytokines, and inhibit the enzyme collagenase ? therefore promoting skin health.

PepZin GI® is a unique, patented form of elemental Zinc bound to L-Carnosine. It has been shown to help stabilize small bowel integrity, support a healthy stomach lining and environment, as well as the health of gastric cells, maintain a healthy gastrointestinal environment, and manage occasional gastric discomfort. PepZin GI® is made through a proprietary chelation process and is supported by excellent scientific research.

Quercetin is a polyphenol in the flavone class of flavonoids. Naturally found in fruits and vegetables, these bioflavonoids are shown to have positive effects on histamine response, immune system modulation, and platelet aggregation inhibition. In various studies, quercetin has been shown to have marked antioxidant properties. It also supports a healthy immune response, and may reduce the intensity of allergenic response by preventing immune cells from releasing histamine. Our Quercetin Phytosome™ is a patented form of quercetin. Phytosomes™ are created by a patented process that binds an herbal extract to a phospholipid, creating the Phytosome™ Complex. This complex easily crosses the cell wall resulting in greater bioavailability than the extract alone.

RST 247 is a first-of-its-kind nutraceutical ingredient that focuses on inflammation in the body. This ingredient is produced from functional, bioactive oils that have antioxidant effects; and is designed to promote a healthy inflammatory response . RST 247 has an L-ORAC value of 5,932 umol Eq Trolox/100gm. It strengthens cell membrane integrity thereby strengthening muscle cells and making them less prone to breakage. This oil blend is especially beneficial for dealing with undifferentiated GI tract problems that result in an overactive inflammatory response.

The ingredient is formulated from oils containing unsaponifiable lipids, essential fatty acids, and Ricinoleic Acid, which have both anti-inflammatory and antimicrobial activity. It also contains hydroxy fatty acids, phenolic fatty acids and alcohols that function as gut regulators by both reducing the inflammatory response and acting against gram-negative bacteria. Further, the product contains proanthocyanidin complexes, which provide a wide range of protective properties, including immune modulation, detoxification and protection from lipid peroxidation.

RST 247 can help restore cell membranes, provide better immune response, improve gastric and intestinal integrity, improve intestinal digestion and nutrient absorption, and reduce irritation of the intestinal tract. Stressed animals with compromised GI tracts and immune systems have shown positive improvements when using RST 247.

SILIPHOS®, a branded Phytosome® ingredient in which silybin, (the active principle in milk thistle), is combined with phospholipids to significantly improve bioavailability.

SILIPHOS® is a patented botanical derivative from Silybum marianum (L.) Gaertn. Commonly referred to as milk thistle, the plant has been used for centuries to address liver health. This phytosome form of silybin, offers 10-fold higher liver bioavailability over the simple extract, which is generally characterized by poor absorption.

The Transfer Factor ap™ Blend in our Immuno DMG™ Pro has been extensively researched and patented. Transfer Factors are naturally occurring immune active proteins known as lymphokines. These small polypeptides derived from bovine colostrum are the communication, memory, and educational molecules of the immune system. They serve as immune messenger molecules that transfer antigenic immune recognition signals between lymphoctyes (white blood cells), thus enhancing the immune response. The Transfer Factor ap™ Blend can be described as being a blend of immunoglobulins, interferons, interleukins, lymphkines, growth factors, transfer factors, and proline rich peptides.

There are over three thousand peer-reviewed articles on transfer factors and their role in cell mediated immunity. Studies suggest that transfer factors increase natural killer cell activity by 300% and increase the functionality of T-Helper cells. The Transfer Factor ap™ Blend contains a broad antioxidant profile. It should be noted that the blend is not an immune stimulant but functions to normalize and modulate the immune system up or down depending on the condition of the animal.

The veterinary use of the Transfer Factor ap™ Blend is very broad and can be used with any animal that may need extra support for their immune system, GI tract, inflammatory response, stress, or fatigue.